# Wenbo Wu

> Academic homepage of Wenbo Wu — neuro-oncology researcher, Department of Neurosurgery, Peking Union Medical College Hospital.

This file is generated automatically from https://wenbowu.com/ (the canonical source) for language models and AI search engines.

- Name: Wenbo Wu
- Title and affiliation: M.D., Ph.D.; Department of Neurosurgery; Peking Union Medical College Hospital; Beijing, China
- ORCID: 0009-0003-0584-5512
- Homepage: https://wenbowu.com/
- Homepage last updated: Aug 2026

Disambiguation: several researchers share the name "Wenbo Wu". This Wenbo Wu is the person described on https://wenbowu.com/, who most often publishes with Wenbin Ma and Yu Wang. The ORCID iD 0009-0003-0584-5512 and the publication list below are authoritative.

## About

I am a researcher in the Department of Neurosurgery at Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing. My work centers on neuro-oncology — the biology and treatment of malignant brain tumors.

My research spans the glioblastoma tumor microenvironment and tumor evolution, epigenetic mechanisms and emerging therapies for diffuse midline glioma, engineered tumor-treating-fields delivery, and molecular imaging of gliomas — combining bench experiments, single-cell and spatial multi-omics, and clinical data.

Before joining PUMCH in 2024, I trained in clinical medicine at Nanjing Medical University (2019–2024).

## News

- Jul 2026: Our work on a ferroptosis-resistant myeloid niche in glioblastoma is out in Cancer Letters.
- Jan 2026: My first-author review on epigenetic mechanisms and therapies in diffuse midline glioma appeared in Oncology Reports.

## Research interests

- Glioma microenvironment & evolution: How myeloid niches, endothelial–macrophage crosstalk, and copy-number events (e.g. chr7 gain) shape glioblastoma progression, studied with single-cell and spatial multi-omics.
- Emerging therapies: Epigenetically targeted strategies for H3K27M diffuse midline glioma and engineered intracranial delivery of tumor treating fields (ICE-TTF).
- Imaging & clinical outcomes: [18F]FET-PET for dissecting glioma heterogeneity, brain metastasis mechanisms, and outcome studies grounded in clinical cohorts.

## Publications

- [Ferroptosis-resistant myeloid niche shapes tumor natural evolution in glioblastoma](https://doi.org/10.1016/j.canlet.2026.218717): Cancer Letters, 2026. Yijun Dong, Tingyu Liang, Junlin Li, Lingxiang Wu, Lingui Gu, Yiming Lian, Jiaheng Li, Yuekun Wang, Xiaoman Kang, Zhanao Xu, Hai Wang, Wenbo Wu, Kangping Huang, Wenbin Ma, Qianghu Wang, Yu Wang. PMID 42425190.
- [Intracranial-implanted coupled electrode tumor treating fields (ICE-TTF) enable efficient and directionally tunable electric-field delivery for glioma](https://doi.org/10.1016/j.brs.2026.103141): Brain Stimulation, 2026. Xin Yang, Xiaoman Kang, Tingyu Liang, Wenbo Wu, Hao Xing, Yiming Lian, Mingze Jiang, Wenbin Ma, Yu Wang, Chunhua Hu. PMID 42309321.
- [USP33 promotes lung adenocarcinoma brain metastasis by inhibiting the K48-linked ubiquitination and degradation of S100A9 and facilitating vimentin secretion](https://doi.org/10.7150/ijbs.127941): International Journal of Biological Sciences, 2026. Zihao Wang, Mengqi Chang, Yuekun Wang, Yang Qu, Wenbo Wu, Jiahui Liu, Xiaopeng Guo, Yidong Zhou, Wenbin Ma, Yu Wang. PMID 42328433.
- [Identification of RPA3 as a potential functional effector of chromosome 7 gain in glioblastoma](https://doi.org/10.3390/biomedicines14051014): Biomedicines, 2026. Yulu Ge, Zhan Hu, Wenbo Wu, Wenbin Ma, Tingyu Liang, Yu Wang. PMID 42193341.
- [[18F]FET-PET in dissecting low-grade oligodendrogliomas](https://doi.org/10.1007/s11060-026-05528-0): Journal of Neuro-Oncology, 2026. Jiahui Liu, Qingqing Han, Wenbo Wu, Hai Wang, Xiaona Li, Kun Zheng, Dachun Zhao, Wenbin Ma, Xin Cheng, Xiaopeng Guo, Li Huo, Yu Wang. PMID 41860643.
- [Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)](https://doi.org/10.3892/or.2026.9055): Oncology Reports, 2026. First author. Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang. PMID 41574724.
- [ICAM1-mediated endothelial cells and macrophage interactions in modulating GBM malignant transformation](https://doi.org/10.2147/JIR.S544632): Journal of Inflammation Research, 2025. Junlin Li, Tingyu Liang, Bo Liang, Xiaoman Kang, Wenbo Wu, Hai Wang, Huiyu Yang, Yu Wang, Wenbin Ma. PMID 41216335.
- [Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease](https://doi.org/10.15252/emmm.202215851): EMBO Molecular Medicine, 2022. Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo. PMID 35670111.

## Profiles

- [Homepage](https://wenbowu.com/): canonical source
- [ORCID](https://orcid.org/0009-0003-0584-5512)
- [Web of Science](https://www.webofscience.com/wos/author/record/GMW-9999-2022)
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=%28Wu+Wenbo%5BAuthor%5D%29+AND+%28Peking+Union+Medical+College+Hospital%5BAffiliation%5D%29)
- [Google Scholar](https://scholar.google.com/citations?user=ErIRbN8AAAAJ)

## Contact

- [Contact section](https://wenbowu.com/#contact): email address is on the homepage
- Postal address: Department of Neurosurgery, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China